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I was given this by a collegue - an expert in biotech - as a introduction to DNA sequencing and Genomics. I started to read it several months ago but put it down, mainly because it's organized as a dictionary of terminology, which I initially found uninteresting. It was only after my friend gave a seminar on DNA sequencing, which I found very understandable...well...MOSTLY understandable, but more importantly TERRIBLY exciting, that I picked up Farkas' book again. NOW it's REALLY useful, especially since he cross-references the definitions to other terms. In fact, SO useful, I woke up at 3:30AM thinking about "Expression" and got up at 4AM to continue reading it (I'm up to "G" now and going strong).
This is a MUST READ for anyone who is caught up in the excitement of the Human Genome Project and who REALLY wants a solid layman's foundation to be able to, at least, comment critically on the vast amount of misinformation and gross over-simplification that the press throws at us all.
BY way of background, I'm a finance guy from the computer industry. My area of expertise, such as it is, is in the convergence of computers, accounting and finance and information systems...as embodied in computer modeling and simulation. I, with biotech friends, am at the embryonic stage of forming an incubator for emerging biotech companies, hence the interest in DNA Sequencing.
From a picture of Drs. Watson and Crick (circa 1953) to DNA chips (a new device that stands to revolutionize molecular testing) this treatise covers a variety of topics in the rapidly advancing fields of cell biology, molecular biology, genetics and biotechnology as well as the practical applications of these fields in medicine. The book can be read in one sitting or used as a reference guide for preparing late night slides for next morning lectures. An appreciation of biochemistry as it relates to molecular biology is also evident with insightful definitions from A-DNA to Z-DNA, no kidding!
The author, a Ph.D. in cellular and molecular biology, has spent a good part of his career as the co-director of a hospital molecular diagnostics laboratory and is currently employed by a DNA biochip company. Insights from his chosen field appear throughout the book and coupled with his interesting writing style the author has produced a concise glossary style work. He offers poignant descriptions, for example, of "Dolly" (the first cloned animal), electric genes, gene therapy, genetic counseling, genetic engineering, DNA forensic testing, and viral genotyping to name a few. In addition he explains how molecular techniques are used to diagnose specific genetic diseases. Entry definitions range from a few sentences to over a page, many with color figures and tables.
Do not expect tired old definitions or descriptions of cellular processes, for example, "DNA is a double stranded helix made up of adenine, thymidine, guanine, and cytosine...bla, bla, bla", instead you get a neat definition of DNA, "the stuff of life, etc." and a picture showing a dangling ooze of the molecule from a glass rod (reminiscent of an icicle in winter). Do not be mislead however, this book informs at the highest level, even seasoned molecular biologists and biotechnologists will realize the value of this treatise.
Beware of the puns. As the author states " if you don't like my sense of humor, understand at least that any remarks you may find troublesome were intended in the spirit of education and humor." I found most quite witty a welcome change from the usual reading materials (scientific journals) that biomedical scientists and biotechnologists are accustomed to examining.
This treatise is not intended to replace a full length textbook but to deliver comprehensible, easy to read definitions in the field of molecular pathology (diagnostics) and molecular biology. In my estimation it will enable a broad group of people including the DNA novice, patient or even clinician, anyone as the author states "who thirst for more knowledge in matters genetic" to have a greater appreciation of DNA and the myriad applications of DNA technology that will inevitably shape the future of medicine.
Because clinical laboratory procedures continue to see change at breakneck speed and are inevitably becoming more "molecular" in nature medical technologists interested in molecular diagnostics and pharmacogenomics will especially benefit from reading this book.
In conclusion I found the book to be well thought out, concise, readable, entertaining and contain wonderful analogies that make difficult abstract concepts like the genetic code and the polymerase chain reaction understandable.
This book review was written by Paul D. Fiorella, a brief biography follows. Currently I am employed by the Florida Department of Health/Bureau of Laboratories as a molecular biologist in Jacksonville, FL. I received my Ph.D. at the State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Department of Biochemistry and did postdoctoral work in the area of environmental microbiology at the Armstrong Laboratory, Tyndall Air Force Base, FL. I also give lectures and educate medical technologists in the areas of molecular epidemiology and molecular diagnostics.
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This book is in no way a polemic about psychotherapy. It is factual, clear and objective in the presentation of findings. For those interested in knowing more about the process of psychotherapy this book details the critical components of the psychotherapeutic process. I know of no other book that presents as clear a picture of the psychotherapeutic process. The book will have an appeal to both the lay person and the professional interested in psychotherapy. It can be used for training purposes as well for it presents interesting clinical material illustrative of the authors' findings.
The book reads quickly and you come away feeling that you have grasped a topic which can too often be difficult to comprehend.
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The encounter is not without danger. The devil attempts to play upon the boy's possible weaknesses--he tries unceasingly to bully our protagonist; he tries to make him feel guilty for the unavoidable accident involving a hapless fish.
But our young hero is made of more self-reliant stuff, and shows us that a promise made to the devil who negates his half of the bargain, is no promise at all.
I like this book because it demonstrates the benefits of curiosity, courtesy, confidence in your own self-worth, and the utility of washing in matters of hygiene. Also, the pictures are cool.