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Goldberg emphasis is to illustrate the disillusionment that was a direct result of the war. According to Goldberg, the discontent of the twenties was largely due to the early ending of World War I. Goldberg coverage includes: post-war foreign policy, decline of labor, red scare, African Americans, rise of second KKK, anti-immigration policies and the presidential election of 1928. While these areas of discontentment were largely a direct result of the war, there were other areas not addressed in his book.
Goldberg offers a selective picture, but it is not the entire picture. Areas not covered include: (1) the plight of the American farmer, (2) rural and small town discontentment against the larger more industrial cities, (3) conflict between modernist/liberals verse the conservatives/fundamentalist movements, (4) discontent between the generations and the emergence of a youth culture, (5) coverage of sentiment shared by many Americans of the enormous loss of life resulting from the war and the influenza outbreak and its influences on the brief return in the Spiritualist movements and finally, (6) returning veterans with their disillusionment towards the war, government in general, foreign policy and their eventual support of the isolationist movements in the thirties and early forties. Topics absolutely vital for understanding America's post WWI disillusionments.
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Overall it gives a good coverage of spotted microarray technology starting from the preparation of probes and slides to sample preparation and hybridization. In addition to expression profiling areas covered include uses of microarrays for analysis of chromatin immunoprecipitation samples, DNA copy number determination, and detection of genetic polymorphisms (oligo arrays). Tissue-arrays and micro-dissection techniques for sample preparation are also described. The bioinformatics section is less extensive than the experimental parts, but the chapters on clustering, self organizing maps and databases serve as good introductions to these areas. I especially liked the image acquisition, normalization and quality control sections. These reviews presented their material in a very clear and sensible way.
Each chapter starts with a short summary of the relevant background. These introductions are very concise, straightforward, jargon-free and up to date in their references. They are written by leading experts of their fields. In addition, there are several "Information Panels" with similar qualities, covering somewhat more general background material.
This is a very nice looking book; it is a pleasure to look at and to hold. I am sure every lab that uses microarrays could benefit from it.
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reviewed by The Clergy Journal, March 2002
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