I have to say that before reading this book I hated statistics and everythingto do with any type of natural sampling. But this book has changed my life! It's easy to read text and easy to follow examples have reinvigorated my love for statistical sampling. I recommend this to anyone who has any interest in statistics. It will change you life too!

When I was Reading this book i got the chills. The creative quality of the statistics and inciteful view of populations is so rad. I love this book.

I use this book every day in my classroom. We use Saxon math and this complements the Problem of the Day very well. I have students complete one problem a day and it is great.

Lee Martin is the best author I know! This is her best book yet. I enjoyed it very much. Martin writes wonderful police procedurals, and every one of them will keep you on the edge of your seat. Bird in a Cage is very interesting, and I reccomend it to anyone who likes mysteries or suspense stories. If you are a Lee Martin fan, this book is a must have for you!

Every one that, being in sport, coaches children and wants to do this job having always in mind the interests and the needs of children and youth that is near him, must read this book because it provides him with different kind of informations, from physiology to pedagogy, but mainly because the book will give him the fundamentals to built a philosophy for his work with young people.

Wow! Who knew Biostatistics could actually be fun? It had been a several years since I'd had any courses in this subject and my memory of it was that it was difficult and rather dry. But as soon as I popped in this CD, it was like learning it all over again. And this time it was a lot of fun!

To have the material presented the way it is in this software (ie-using really cool multimedia), makes it not only very understandable, but very interesting as well. I'd certainly say this is a must for a student or anyone else interested in Biostatistics.

This is a technical book written by psychiatrists for physicians interested in Cytochrome P450 (CYP) enzymes and how these systems affect the metabolism of commonly prescribed drugs. Interest in these enzymes was heightened by problematic drug-drug interactions that lead to several fatalities and the removal of some prescription drugs from the market. Since then, there has been a heightened awareness by physicians, especially when prescribing drugs that inhibit one of these enzymes. From a clinical perspective, several questions are difficult to answer. For example, referring to commonly used tables or references it may be difficult to figure out why a particular drug has accumulated. It is also difficult at times to figure out a specific time course of action. When a drug is discontinued - how long does it have an effect on CYP systems? How immediate is the effect when it is started? Which drug-drug interactions are significant and which are not? This book provides a good deal of information in all of these areas.

The layout of the book is interesting and practical. The authors start out with a review of the 6 CYP systems as separate chapters. They start out with the most well characterized systems. They look at enzyme locations, metabolic activity, polymorphisms, inducers and inhibitors. They also provide vignettes of typical problems at the end of each chapter. A good example of the level of analysis in this book is contained in the brief vignette at the end of the 2C9 chapter. They describe a case of phenytoin toxicity that occurs when fluoxetine is added to phenytoin maintenance therapy. Their comment is: "Phenytoin is metabolized by 2C9, 2C19, and phase II conjugation systems. Although not a potent inhibitor of 2C9 and 2C19, fluoxetine does inhibit these enzymes and most certainly was the cause of this woman's increase in phenytoin levels". Comparison with other methods of checking these interaction usually does not provide this level of detail. Commonly used drug interaction programs may attribute the accumulation of phenytoin to "decreased metabolism" and point out that other compounds also have this effect. Drug interaction cards or charts might count on you being able to see both phenytoin and fluoxetine in two different columns and making the connection. The authors' analysis pulls all the relevant facts together in one place.

Chapters specific to Gynecology, Internal Medicine, Infectious Diseases, Neurology, Oncology and Surgery follow the initial chapters on CYP enzymes. Specific clinical examples of relevant drug- drug interactions are given in each chapter. As an example, the Gynecology chapter discusses the issue of contraceptive failure due to enzyme induction. Specific prescription drugs and a potential problem with St. John's wort are discussed. These chapters are all clinically relevant and well referenced.

The book concludes with two appendices - one about how to search the literature and very well written Appendix A. Guidelines for Prescribing in a Polypharmacy Environment. Polypharmacy has become the rule rather than the exception these days as more therapeutic agents are added to treat multiple illnesses in the same patient. In fact, in some situations multiple agents from the same therapeutic class are being used to treat refractory problems. The authors suggest five principles for physicians to use that decrease the likelihood of drug-drug interactions. These guidelines are adaptable to individual practices and allow the clinician to choose a profile of medications with the greatest level of safety. The book also contains a pocket guide called "P450 Tables" that summarizes the interactions listed on specific chapters.

My particular bias as a practicing physician is that I need to know the information in this book. After attending seminars on the topic, reading journal articles and pharmacology texts, and using several computer programs on drug interactions the information presented in this book is comprehensive and unique. As a paperback book it is also inexpensive. It is a book that should be read by psychiatrists and other physicians who prescribe medications to patients using other prescription or over the counter medications.

George Dawson, MD

I have read several of the Deb Ralston series books and liked all of them immensely. These are books wonderfully suitable for someone looking for a cross between a cosy and a more modern, realistic mystery. Deb is neither a superwoman, a burn-out, or a sweet little old lady; she is a wife and mother who handles her duties as a police officer in a matter of fact manner. I like the direct, no nonsense attitude she displays, but she is neither cold nor hostile, just refreshingly normal

Cooperative learning at its finest is the motto of this little marvel. This book is filled with reproducibles and extensions to each unit. Everyday items are collected and graphed while children anxiously await the outcome of the data tallies. I really enjoyed the ease of using this book and the excitement that was generated by "great graphing."

Deb Ralston mysteries are very addictive, and this one is no exception. I didn't get to read them in order, which would have been preferable since developments in the lives of the characters then make a lot more sense. In this one, Deb is almost nine months pregnant with Cameron at the beginning and is the only one who can go to New Mexico to find her errant son Hal and his girlfriend Lorie, who hitched a ride there together without permission during spring break. Of course, Hal is eventually found in a sleeping bag next to the murdered body of a young woman, and Lorie turns up missing. So Deb ends up helping the police chief of this very small town in investigating the murder (and finding Lorie) so that Hal can be cleared of the whole thing and they can go home. Although there is a lot of tragedy and sadness in this book, much humor is evident throughout...I have read this book over and over, laughing at how funny/difficult it is for adults to get through to Hal, who lives seemingly in a world of his own logic. :)

I have read both of Dr. and Emily Lee's books, and in my opinion they are the best teachers of the art of tai chi and how it relates to healing the body and also the mind. Relax, breathe, feel the earth. Do nothing extra. This is Doctor Lees philosophy and approach to tai-chi. I wish I could give it six stars. Doctor Lee and his family are a pure gift to those who will follow there teachings.
Peace.