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To gather wonderful tales of how Scorsese works, Kelly interviews the director's friends, family members, casts, and crews. Oh, and the Secretary to the President of Cyprus!! (See details about The Last Temptation of Christ). Quoted stories, observations, and comments all contribute to a fine portrait of one of our greatest active cinema artists. (And, to the delight of film buffs everywhere, text shows that Scorsese is first and foremost an unabashed movie fan)! Kelly's system provides the reader to form own opinions about Scorsese, rather than making a lot of critical conclusions.
In pursuit of my undergrad degree, I used this book quite a bit for research toward essays I wrote about Scorsese's films. Not at all a chore to read, it was a very enjoyable book, great for the fan as well as the film scholar.
Good index, good filmography. Brief forewards by Michael Powell and Steven Spielberg hint at more than a bit of pure jealousy!
BUy it!
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Although the existence of the structure was known since Charles Campbell discovered it in 1699, its premier significance as a repository of ancient art, architecture and symbolism was never fully realised until Prof. O'Kelly and his team set about their work. The phenomenon of the roofbox, which for 7 minutes at dawn on the days of the winter solstice fills the central chamber with light, is incredible. I have visited the site more than 30 times, and had the privilege of a solstice viewing in 1994. I cannot recall a more fundamentally spiritual experience in my life.
This book has it all. The non-academic reader (I am one such!) may find certain sections a little turgid, but there are plenty of discussions on the mythology and symbolism to compensate for all the facts and figures if the latter don't suit. The illustrations are superb (photos, maps,pen/ink); the footnotes comprehensive, the objective analysis is compelling and the whole project just so worthwhile.
The reader can also enjoy placing their own interpretations on the significance of the carvings, objet d'art and the Solstice phenomenon, and be just as valid as anyone else. After all, the original builders left this earth 6500 years ago and didn't leave a users manual!!
Enjoy. 5 Stars (and the sun and moon as well!)
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The only part that I found to be a joke is at the very beginning, concerning how to conduct a job search. The instructions are so general that they are useless and the cover letter and resume examples are only mildly useful. More importantly, information like that is already readily available in better and more detailed format on the internet, so they could really have just saved some paper and left this part out.
The bottom line is that this book is a crucial reference guide for companies you could be applying to that you didn't even know existed until you got this book. Since it narrows things down to one metropolitan area instead of a region or the nation as a whole, it allows the author to list even more employers for this specific city and with even more detail.
A must have if you are doing a focused job search!
The layout of the book is interesting and practical. The authors start out with a review of the 6 CYP systems as separate chapters. They start out with the most well characterized systems. They look at enzyme locations, metabolic activity, polymorphisms, inducers and inhibitors. They also provide vignettes of typical problems at the end of each chapter. A good example of the level of analysis in this book is contained in the brief vignette at the end of the 2C9 chapter. They describe a case of phenytoin toxicity that occurs when fluoxetine is added to phenytoin maintenance therapy. Their comment is: "Phenytoin is metabolized by 2C9, 2C19, and phase II conjugation systems. Although not a potent inhibitor of 2C9 and 2C19, fluoxetine does inhibit these enzymes and most certainly was the cause of this woman's increase in phenytoin levels". Comparison with other methods of checking these interaction usually does not provide this level of detail. Commonly used drug interaction programs may attribute the accumulation of phenytoin to "decreased metabolism" and point out that other compounds also have this effect. Drug interaction cards or charts might count on you being able to see both phenytoin and fluoxetine in two different columns and making the connection. The authors' analysis pulls all the relevant facts together in one place.
Chapters specific to Gynecology, Internal Medicine, Infectious Diseases, Neurology, Oncology and Surgery follow the initial chapters on CYP enzymes. Specific clinical examples of relevant drug- drug interactions are given in each chapter. As an example, the Gynecology chapter discusses the issue of contraceptive failure due to enzyme induction. Specific prescription drugs and a potential problem with St. John's wort are discussed. These chapters are all clinically relevant and well referenced.
The book concludes with two appendices - one about how to search the literature and very well written Appendix A. Guidelines for Prescribing in a Polypharmacy Environment. Polypharmacy has become the rule rather than the exception these days as more therapeutic agents are added to treat multiple illnesses in the same patient. In fact, in some situations multiple agents from the same therapeutic class are being used to treat refractory problems. The authors suggest five principles for physicians to use that decrease the likelihood of drug-drug interactions. These guidelines are adaptable to individual practices and allow the clinician to choose a profile of medications with the greatest level of safety. The book also contains a pocket guide called "P450 Tables" that summarizes the interactions listed on specific chapters.
My particular bias as a practicing physician is that I need to know the information in this book. After attending seminars on the topic, reading journal articles and pharmacology texts, and using several computer programs on drug interactions the information presented in this book is comprehensive and unique. As a paperback book it is also inexpensive. It is a book that should be read by psychiatrists and other physicians who prescribe medications to patients using other prescription or over the counter medications.
George Dawson, MD
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Pity.
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Following her careful, yet simple, instructions and tips, will make for wonderful cookies and brownies. These are the best chocolate chip cookies I have ever made, and I have tried several recipes, and the apricot/lemon bars were also a big hit. I am going to make several of the recipes here for Easter sunday with the family, and I am confident that they will be well received.
Ms. Medrich's other cookbooks are on my wish list because her recipes are to me, the standard in dessert making.