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However, most botanist may not be pleased to know that little attention was paid to plant viruses. Again, many potential buyers may be demoralized by the rather high price that this virology-set demands.
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The authors do a good job of describing the relevant equations needed to model virus dynamics. The book would be a good beginning for mathematicians interested in going into the field of mathematical immunology. And, even though it should be classified as a monograph, rather than a textbook, since there are no problem sets, students of mathematical immunology should find this book a useful introduction to the subject. In addition, the authors give a large list of references at the end of each chapter for further reading.
Mathematicians who need a background in the biology of the HIV virus will find a good discussion in Chapter 2 of the book. The authors give an historical summary of the origins and treatment of the virus in this chapter. This sets the stage for the mathematical modeling of virus dynamics in Chapter 3, where the authors define the basic reproductive ratio and write down a system of three coupled nonlinear ordinary differential equations as the basic equations of virus dynamics. They remark, though without justification, that an analytical solution of the time development is not possible, and so they use approximation schemes to solve the equations. The equations are a phenomenological representation of virus dynamics, and no attempt is made to relate the rate constants to the underlying microscopic properties/structures/processes of viruses. They do however discuss the empirical data associated with studies of SIV infections, and show convincingly there is a correlation between the initial growth of the virus and its value at equilibrium. They caution the reader that the basic model does not give the true reproductive ratio, and show how to correct for this by introducing time delays.
The efficacy of drug therapy is treated from both a mathematical and experimental viewpoint in the next chapter. This is a very enlightening discussion from the standpoint of the validation of the virus models.
The authors switch gears in the next chapter and talk about the dynamics of the Hepatitus B virus. Again, they do a good job of introducing the reader to the experimental evidence for the models of this virus.
In chapter 6, they bring in the contribution of the immune system to the basic equations. They assume that the reader is familiar with the concept of CTL responsiveness. The resulting equations are somewhat more complicated, and the authors show how the ubiquitous Lotka-Volterra equations arise with the virus being the prey, and the immune system the predator. No detailed phase space analysis is done however to study any of the equations in this chapter, which would have been useful to the reader.
The chapter on quasispecies is the most interesting one in the book, as the authors not only give a rudimentary definition of quasispecies, but they also give an indication of their complexity. Disappointingly, they mention the idea of mutation rates and their connection with chaos and self-organized criticality, but do not elaborate on this at all.
The Bonhoeffer's laws of anti-viral treatment are discussed in the next chapter and the authors show how to derive them using the basic model. The emergence of resistance during drug treatment is modeled by parameters which reflect the replication rates of the virus, but these parameters are again not connected with any underlying microscopic properties of the virus.
Some interesting dynamical behavior occurs for the case of multiple epitopes where the existence of quasiperiodic oscillations is shown to occur. They authors refer to this as "unpredictable" but they do not define this term in the book. The existence of quasiperiodic orbits in a dynamical system does not by itself make the system "unpredictable" or random of some sort.
This book is a very addition to the literature, and most importantly, it emphasizes the role of validating mathematical models experimentally, which takes on even greater importance given the medical ramifications of the topics in this book.
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"Whether or not Schulz is a devout Christian I could not say," writes lexo-2. If he had taken the trouble to actually read Short's book, however, he would have found numerous quotations from Schulz himself concerning his religious views. Speaking of a Bible-study group he attended shortly after his return from the Second World War, Schulz says, "The more I thought about it during those study times, the more I realized that I really loved God" (quoted on p. 70). Or again, "I don't even like the expression 'take communion.' You cannot 'take' communion. You are a part of the communion. You are communing with Christ; you are a part of the community of saints" (p. 80). The rhetoric, complete with its anti-Catholic bias against the notion of "taking" communion, is clearly that of a born-again evangelical (in Schulz's case, Church of God). And lest there be any doubt of Schulz's authorial intentions, he is quoted in the very first chapter as saying, "I have a message that I want to present, but I would rather bend a little to put over a point than to have the whole strip dropped because it is too obvious. As a result . . . all sorts of people in religious work have written to thank me for preaching in my own way through the strips. That is one of the things that keeps me going" (p. 20).
Schulz was worried about being too obvious. Clearly he wasn't obvious enough.
Short's book is cogent and well argued; it certainly is not a collection of "homilies." Contrary to what lexo-2 implies, Short does not ignore the darker side of the Peanuts world. Indeed, of lexo- 2's "three phrases," Short uses two or them in chapter titles: "The Wages of Sin Is 'Aaaugh!'" and "Good Grief!" Good grief! Read before you review!
Yes, lexo-2 is quite right that the world of Peanuts is a "sunlit hell, in which the characters never grow, never change, etc." Where he goes wrong is in assuming that Short--a Ph.D. in literature and theology, a man who had taken the trouble to study the cartoon in depth and even write a book about it--couldn't see that for himself. Wrong, wrong, wrong. Short's whole point is that we all live in a "sunlit hell," suffering "unimaginable fears" and "wreaking appalling cruelties on each other," and that we will never escape that hell unless we can find . . . (you guessed it!) the saving grace of Jesus Christ. The salvationist message does not come across too strongly in the cartoon (Schulz did not want to be "obvious") but it just as surely is there, between the lines, in the occasional epiphanies of love and reconciliation that illuminate the otherwise bleak moral landscape of Peanutopia.
You can agree or disagree with the Short-Schulz analysis of the human predicament. Personally, I disagree strongly. But in a world in which evangelical and fundamentalist Christianity have so much influence and power, it simply will not do to be idly dismissive. Indeed, I particularly recommend Short's book to freethinkers of every stripe, if only that they may remind themselves just how subtle and persuasive evangelical discourse can be. There is more, much more, to Short's little book than "pious ramblings" and that is precisely what makes it, depending on your point of view, so inspiring or so insidious.
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