An in depth look at the area of study giving the reader a greater understanding of the subject.

This is one of the best books I have read on Chemical Sensitivity. Matthew's has lots of very good information. This book is a great resource to have in your MCS/Chemical Sensitivity Collection. I highly recommend this book. I would not be without my copy!

Chemical Sensitivity, By: Bonnye Matthews is a "Must Have" book, especially for those new to MCS. It contains detailed information, and provides excellent resources. Written in a professional, yet easy to read format, I recommend it for anyone's MCS medical/resource library!!!

This is an incredible book. However, one problem is that it does not include some other literature on MCS(S).

To make another criticism of the book, are the problems I see with pages 31-58, which describe a porphyria model of etiology. Bonnye says there are 3,000+ chemicals--including perfumes-- that trigger porphyria attacks. She does not cite much evidence for this except for a paper written by Wilson. She also fails to take into account of this theory (even though she notes it), that not all MCS sufferers test positive for porphyria, even during reaction. Nor are there any controlled experiments of the theory. So the data suggest an association of MCS with abnormal porphyrin metabolism, but not a MCS etiology of such. Bonnye goes as far as to say the porphyria model is the first model on MCS, which is ridiculous.

Now on to some positive book discussion/ review. Donald Dudley, M.D., wrote a chapter that discussed the research he has performed. Dudley studied the Auditory and Visual evoked potentials of twenty patients with MCS (under Cullen's definition). Auditory and visual P300 were influenced "significantly" when the olfactory system was stimulated with chemicals that had six or fewer carbon fragments. The patients were exposed to perfume, felt tip pen, and other everyday chemicals in an everyday amount. Left and right P300 auditory were greatly decreased upon chemical exposure. Though the visual P300 was not decreased to the same degree (but decreased none the less), there was a significant change in waveform quality that caused two patients to have occipital seizures. In other words, the brain waves of MCS sufferers go haywire upon being exposed to chemicals they are sensitive to. This is not the work of psychogenic disorders. (See pg.24, summary of "MCS: Trial by Science")

Neurotoxicologist Dr. Gunnar Heuser has a chapter in which he discusses his research on brain scans before and after chemical exposure. MCS patients generally have a decreased flow of blood to the *limbic region* of the brain, which becomes further decreased upon exposure to perfumes (see pgs. 27-30)

I find chapter 7 to be both enlightening and disturbing: It discusses the fact that there are seven major studies that are used to show MCS is a psychogenic condition. In these seven studies, there were a total of 334 patients studied. However, no more than thirty-three of these patients actually had MCS. In five of the studies, none of the patients had MCS. Of the remaining two, in one study, eighteen out of forty-one had MCS, and in the other study no more than fifteen out of fifty-three had MCS. Thus, it is fair to state that the studies have nothing to do with the real MCS. (See pgs 111-130)

The conventional medical community is contradicting itself, which is one reason I've lost faith in conventional medicine.

In sum, this book is excellently written as it contains a clear presentation of useful data. I strongly recommend buying it.

Highly recommend it! It is evident that special interestswillnot like it as it is not within their financial interests! Nowwith new emerging evidence it becomes the issue of emerging credibility!

This book comparing to trashy campaign published disinformation campaign sponsored by special interests ... is undisputed MASTERPIECE! WHAT ELSE ONE CAN SAY?

Only works of Claudia Miller, Mohamed Abu Donia, Marc Cullen, Grace Ziem the MDs scientists and researchers could be rated any higher!

Together with other jewels and masterpieces such as: Chemical Exposures: Low Levels and High Stakes, 2nd Edition; Claudia S. Miller, Nicholas Askounes Ashford the readers can get full accounting of the magnitude of informations available today from first hand witness of the suffering.

To add to credibility to this book read scientific review by Alexandra Golub a DOD scientific review sponsored under PENTAGON and DOD programs on Gulf War illness research... demonstrates that there is clear the connection between neurological injury and MCS. Only by reading such first hand accounting and documented evidence one can get full image of the magnitude of legal deception by any and all means!

The recent findings in reference to heavy metals and specificaly mercury toxicity and neural sensitisation, as the cause of developing heavy metal allergy suported by the newest MELISA (memory lymphocyte immuno-stimulation assay) tests with the study of metal-induced neural neurotoxic sensitization tests

could beef up the splendind factual accounting by this the autor first hand of the mysery of injured by neurotoxic agents.

As far as discussed treatment it is difficult to treat what is not yet fully explored there for elimination and avoidance is what must be first considered.

The NEW emerging scientific evidence only adds credibility and supports this book. The recent findings of brain damage in Gulf War Veterans, as well as ethiology of allergy and asthma ...reported on May 18, 2000 with new evidence that the ALLERGY NERVE GROWTH FACTOR NGD was linked to NGF proteine.

"Hopkins allergy researchers took to the trail of NGF for several reasons. First, Koliatsos, who is an expert on the use of NGF in experiments to treat nerve and brain disorders, informed the allergy researchers that using NGF to treat Alzheimer's caused patients excessive pain. NGF, found naturally in the body, is a small, potent molecule that helps maintain certain nerve cells and prods other nerve cells to grow and communicate with others. "It looked like the pain syndromes we saw in these patients shared many of the same mechanisms with respiratory allergy," says Koliatsos. "

The new evidence clearly demonstrates a valid what previously was unknown missing links: "Hay fever and asthma now seem to derive from events not only in the respiratory system, but also from a nervous system that is overreacting to stimuli," says Vassilis Koliatsos, M.D., an associate professor of pathology, neurology and neuroscience at the Johns Hopkins School of Medicine."

God bless autor for excellent account of factual presentation of the REAL WORLD of what I will plainly call "QUACKERY and fraud in medicine".

A Must READ!

"Defining Multiple Chemical Sensitivity" is a carefully documented story, written to establish knowledge and truth based on scienfific method. The first chapters cover some of the latest work in biomarkers for demonstrating chemical poisoning. This poisoning may occasionally be followed by the complex of symptoms called Multiple Chemical Sensitivity Syndrome (MCSS). Biomarkers (medically verifiable tests) include measurable changes in molecules, biochemistry, or cells from human tissue or fluids. Included here are auditory and visual evoked (or "event-related") potentials (ERPs), SPECT scans, acute intermittent porphyrinuria, and changes in levels of cytochrome P-450. These papers go a long way towards providing an understanding of why the chemically poisoned experience such brain fog and react to so many things. There is information on how to prevent/counter attacks. Donald Dudley's chapter, "MCS: Trial by Science" shows how the influence of the olfactory system has been quite underestimated in medical science. 20 MCS patients (under Cullen's definition) were exposed to substances like formaldehyde, MEK, perfume, diesel, a whiff of felt pen... - all chemicals having 6 or fewer carbon fragments in their volatile component. Neurotransmitters from the olfactory system (like glutamate and NMDA), also have molecules with this structure. It is thought that the 6-or-less carbon chemicals act as agonists for the glutamate and other amino acids. And these are the same amino acids which are implicated in brain cell injury - eg stroke, pain, depression and degenerative brain disease. In the study, stimuli were given to eyes and ears - a changing checker board and clicks, before and after the chemical exposures. Electrodes measured how long the brain took to react and how much brain reaction there was. The findings were dramatic. Gunnar Heuser's chapter covers SPECT brain scanning; pictures of the brain which show how the oxygen-carrying blood flow is impaired in the frontal, temporal and parietal lobes in people with exposure to neurotoxic chemicals. This hypoperfusion is further decreased on exposure to, for instance, perfume. Mathematical tasks did not light up the appropriate areas of the brain. He suggests possibilities to explain these findings. These kinds of brain affects were actually detected in a study on DDT in 1966; this research was never followed up. However progress is being made - I liked Eileen McCarty's first chapter parting shot: "A cosmetic salesperson related her poorly adhering nail polish to the lessening of formaldehyde in the formula...". The book has lots of interesting "bits". Porphyrias are deficits of certain enzymes required for the production of heme. Heme is used to produce haemoglobin (for carrying oxygen and carbon dioxide in the blood), and cytochromes (for breaking down such things as steroids, drugs, pollutants, mutagens and natural plant and animal products. Prozac and aldehydes have been shown to inhibit cytochrome P-450. Porphyrias were an extremely rare hereditary condition (remember "The Madness of King George?") usually with a single enzyme missing. But specific testing (through the Mayo Lab) shows how a chemical exposure can cause a multiple enzyme deficit. Bonnye Matthews, in this chapter, gives a clear explanation of the process. She demonstrates that for the first time a model of MCSS is possible. Some Gulf War veterans have also tested positively for toxic-induced porphyrias. The information in this chapter on the substances which can set off an attack is vital. Though there is a great deal of common sense in this book, it's not a light read - there's necessary information for medical professionals - GPs, neurologists, neuropsychologists, psychiatrists, occupational health physicians, allergists, immunologists, cardiologists, gastro-intestinal specialists, anaesthesiologists... in fact it should be compulsory reading at medical schools and for all practising doctors, such are the wide-ranging affects of chemical poisoning. Bonnye unravels the medical detective story that is behind MCS Syndrome - the unethical and incompetent research and papers and medical assessments which were designed to deny compensation by showing MCS as psychosomatic. (The spinoffs are that these papers are now used in countries like New Zealand to deny claims based on MCSS.) But the book's not a witch-hunt - more of a plea for justice and open-mindedness in establishing facts. Bonnye Matthews also tells her own story - because she was (unwittingly at first) in the thick of it as a research subject and recipient of workers' compensation (for a while anyway) in Washington. Her unecessary medical procedures - the methacholine challenge, the venous punctures, even being forced to attend appointments downtown against the advice of her treating physicians are horrifying in their consequences. And loads more including a legal section which shows how a scheme which was intended to be no-fault insurance for work-related individuals has become an adversarial process (and this is Washington, not New Zealand). The measured title of this book belies a gripping read which may make you feel outraged and sick. Please read this book.