This is one of the few nonfictional books that I have ever read that I have literally had a hard time putting it down. Dr. Altman not only wrote a book of significant importance about the need for self-experimentation, and the history of it...but he wrote it so well that I wanted to know what and who did the next group of experiments. It also explained a lot of procedures I learned about in medical school, but sometimes without the knowledge of the history behind it complete understanding is impossible. The author also explains quite clearly why we can't use just animals in experimentation, and gives numerous illustrations of physicians and scientists who...surprise!...actually think about others compassionately and are able to put themselves in the shoes of the patients. After undergoing an experimental cochlear implant which failed (in its early days), this book makes it a lot easier for me to explain to others why I undertook such a risk and didn't sue when it failed and made me ill. The book also makes clear the need for both patient and doctor awareness of informed consent...for all patients, including those who are disabled or those who lack a complete education. Dr. Altman wrote a book that should definitely be required reading by all medical personnel in ethics classes. Karen L. Sadler, Science Education, University of Pittsburgh, klsst23@pitt.edu

This book discusses a taboo in medical research--self-experimentation. The self-experimenters ranged from the oddball to the dedicated, experiments ranged from shots in the dark to well planed out Gives a glimpse into the courage of these men and women. I highly recommend this unusual and thrilling book.

This is a wonderful book about a nearly wholly ignored aspect of medical research - - doctors who are the cutting edge of experimentation. Hopefully it will be in paperback soon

This book takes you throug the depths of reasoning from different angles viz. science, philosophy, spirituality, humanity and more. And the ultimate aim: how ther are just different parts of the same string. Must read !!

With this debut collection of essays, George Klein, Holocaustsurvivor and one of the world's foremost cancer researchers has joinedthe growing list of scientists willing to share their experiences in science with the general reading public. By all accounts, this is an impressive start. The essays range in content from personal anecdotes about science and scientists, travelogues, discussions on virology, genetics and cancer, misuses of science in Nazi extermination camps to reflections on death, religion and ethics. His writing is simple, unpretentious, original and a delight to read. If this gem of a collection is any indication of things to come, we are in for many such treats in the future. Read it, enjoy it, treasure it, this book is a memorable reading experience.

Not since I read Sir Peter Medawar's essays on science and scientists have I encountered such clarity in language and thought and a commitment to portray science as it is really practiced, subject to the same motivations and biases as any other human endeavor. The first section of the book, "The Wisdom and Folly of Scientists" deals with such issues. The tempo and style of Klein's writing is defined early in the book in the essay "The Emperor's New Clothes" (my favorite in this collection). In this story he explains the phenomenon of scientific "conformism", the tendency of scientists to accept or reject a new finding without critical thinking, and how this may hinder or even damage scientific research.

In the essay "Are Scientists Creative" Klein uses the biologist Sol Speigelmann's dilemma, Is my work worth anything? (Something that many scientists must have agonized over at some point) to explore the nature of scientific creativity and to contrast it with the artistic temperament.

In "Ultima Thule" he talks to the German geneticist Benno-Muller Hill about the ugly history of the eugenics movement and its culmination in the mass murder of Jews. How could this have happened? How could respectable scientists commit such unspeakable misuses of science? Were they all psychopaths? Klein discovers some surprising answers. One would have thought that after the excesses of the Second World War and our current understanding of genetics, the theory of genetic inequality would have been finally put to rest. Instead, this distasteful topic keeps surfacing every now and then. H.J Muller's 'genetic deterioration' hypothesis, our attitudes towards AIDS patients and Singapore's "race improvement" program through preferential matrimony are recent examples of such misguided thinking. Will we ever shake ourselves free of these prejudices? Klein offers no easy answers, just a warning to keep vigil.

In the section Viruses and Cancer, Klein displays his abilities to explain the difficult concepts of virology, genetics and cell biology in uncomplicated and understandable language. The essay "The Tale of the Great Cuckoo Egg" is particularly fascinating. It traces the history of cancer research, from the early days when all cancer was thought to be of viral origin to its present state of understanding. The story beautifully illustrates how 'pet theories', coincidences and pure dumb luck all played their part in some of the most important discoveries of 20th century biology, finally leading to the discovery of oncogenes, the growth regulatoy genes of the cell.

La Condition Humaine, the final section, is also the most philosophical, as Klein reflects on our will to live, our sexuality, attitudes towards death and dying and religion. 'Eternal Printemps' begins with some entertaining examples of our attitudes towards sex. Klein uses quite a few examples, from classical music to the sexual mores in Sweden, the Masai and the orthodox Jewish community in Jerusalem to summarize his 'kaleidoscope of sexuality'. A section on sex as a genetic process and how it evolved as the dominant mode of reproduction in the eukaryotes, puts the preceding discussion on human sexuality in a more sobering perspective.

The last chapter 'The Atheist and the Holy City' set in Jerusalem, is his most personal writing. Here, George Klein, scientist, humanist, philosopher, attempts to reconcile his atheist beliefs in a city steeped in religion. No one can convince him of the existence of God. The scars of Auschwitz are too deep to heal. What has this century taught us? Where is mankind heading? Like Peter Medawar, Klein also believes that this century has been what it is because of science, and this conviction resonates throughout his writings.

In the end, this book is George Klein's personal journey, undertaken to make sense of some of humanities most basic constructs; religion, sexuality, ethics and morality, how they conflict with, and are sometimes better understood within the framework of modern biological thought. I suppose, anyone who has lived the life he has, will finally have something to say. As he admits in the preface," the words have welled up in me. I needed only step aside and watch them flow". Indeed they flow, in a calm, soothing, passionate and gently persuasive manner. We need to just immerse ourselves in them to experience the mind of an extraordinary scientist.

I was surprised and excited to receive a signed photo journal from George Thomas. I had looked in books that offered good quality, applicable pictures that I could look at while researching and reading other books (i.e. Undaughted Courage- Steven Ambrose, and Out West- Dave Duncan). I was surprised how hard it was to find a book with many pictures of the trail highlights

This book has not only pictures of the many landmarks along the trail but also suggested old camp sites and river forks described in the story books and journals (I believe they were taken around the same time of year the explorers traveled).

I would suggest this book for everyone!

The photography was breathtaking. It is an excellent book for the layman. I would advise any history buff to read this book. It is also an excellent resource for teachers.

This is one of the few books, along with Careless Technology, Silent Spring, The Limits to Growth and others that really clarified the approach of humankind to nature. It is not a critique of modern technology or society, but an early and valuable presentation of the ecological consequences of human activities throughout history. I thoroughly recommend this book to any students of environmental studies or development issues.

This is an excellent, thoroughly readable collection of scientific studies concerning the role of prehistoric humans in changing the ecosystems they inhabited. The studies range from the extensive farming terraces of China over 5,000 years, to the possible creation of the Great Plains grass ecosystem through Amerindian burning for hunting purposes. Although somewhat dated, this book provides a scope of research that will not be found anywhere else. I read this book thirty years ago during my Anthropology graduate studies at UC Berkeley, and have never forgotten it. I am very happy to see it in print again.

In my senior year of college, we were assigned Natural Obsessions for the relevance to oncology as a science. I had expected, as with all other undergraduate literature, to find only academic value in the book and approached it as such. But what unfolded instead was a journey through the strange and passionate world of research. It is what made me want to become an oncologist.

The nature of the story is of the many races during the 1980s to identify the genes causative of cancer. The narrative largely follows one lab, that of Robert Weinberg at MIT, and details their many setbacks and their even more groundbreaking victories. The author takes an active part, effectively becoming absorbed into the research and drawing the readers with her.

What the book offers, then, is a daily tread through the lives of basic researchers: not filled with sterile labs and stuffy professors, but with the drama, intrigue, and bittersweet triumphs normally found only in fiction. As there are no outright heroes or villains (except perhaps cancer itself), the moral ambiguity of each of the subplots makes the struggles more human. There is as much backstabbing, cut-throat competitiveness, and outright selfishness in the research world shown here as in any other professional field. But there is also collaboration, celebration, and respect. Anyone who thinks basic science is boring should be convinced otherwise.

The other side of the story is, indeed, academic in nature, though interwoven seamlessly with the stories. Despite the heavy scientific concepts throughout the book, Natalie Angier -- a non-scientistist herself -- has taken great pains to evince the most convoluted theories in a light, colorful language. Not all of it will be clear immediately, but the essence of the book doesn't require total familiarity with the technicalities. It is the humanity of the researchers that drives this book, not the research itself.

For undergraduates unsure of thier career choices, I can recommend no better book than Natural Obsessions for deciding if scientific research is for them. For some, like one of my friends who chose med school over grad school, the themes of competitiveness and failure can be disheartening. For others, like myself, it can open up a new perspective on science, one that can be exciting as well as rewarding if you have a passion for it.

This book covers all the in-depth information a person could want to know about cancer, while at the same time not burying the reading in technical jargon and biological confusion. I enjoyed reading this book for the information presented, but also the method in which it was conveyed. A must buy for anyone interested in this terrible disease.

Wolpert's developmental biology textbook is evidently an excellent text in its field. The authors are all well recognized in thier research areas. The organization of the text is also very well written. The summary of the concept presented at the end of each chapter is helpful. The figures presented througout the text are clear and the language used to explain them is simple but very understandable. Compared with the well-known Gilbert's text, this text may be less in dept but you can get the concept from this book for only half of the time reading Gilbert's. It is a nice book to have both for the new beginner in the field and for just a quick reference.

@I read this book for 2 months. Chapters of regeneration is more impressive than any other chapters.Moreover, I impressed that this bppk is best for beginners and students. Composition is also excellent.

This is an enjoyable book of a lifetime spent in the field of medicine. My favorite chapters were the early ones as Thomas looked back at what medicine was like early in this century, including what he remembers from his father's medical practice. This medical reminiscence differs from most other physician's writings in that Thomas has spent the majority of his career in research rather than in the clinical practice of medicine. But if research is often thought of as dull drudgery, Thomas certainly does not reflect that in the book. His genuine enthusiasm (and important finds along the way) have shown how necessary research is to progress in health care. As a clinical physician myself, I gained a new appreciation for this side of medicine. Lewis's enthusiasm is infectious, his comments candid, and his medical poetry quite entertaining. I enjoyed reading this.

My favorite Lewis Thomas, so far. There are many good science popularizers around, the late Carl Sagan being better known because of his TV series - Cosmos. Dr. Thomas' books stand-out as being comfy because of his "fireside chat" way of explaining and telling stories. Why do I call him a "good man"? Because his love shines through in his writing.

This book will numb your mind. It's absolutely incredible, as are all the books in the Princeton Reprint Series.

An exciting tale of the journey of these two adventurers and their crew is retold through sufficient text and plentiful images. The photos are striking and abundant and a great way to lure kids into reading the book. It's both educational and entertaining to learn of their trials. However, if you are looking for expansive, in-depth text of every moment, you should check out other books that are a reprinting of their diaries. While this book is thorough, it is really just an introduction to the whole adventure and easy enough that you'll probably finish it in just a few sittings.

"The object of your mission is to explore the Missouri river, & such principal stream of it, as, by it's course and communication with the waters of the Pacific ocean, whether the Columbia, Oregon, Colorado or any other river may offer the most direct & practicable water communication across this continent for the purposes of commerce." -Thomas Jefferson, Instruction to Lewis, June 20, 1803

The Saga of Lewis & Clark is richly illustrated with lavish full-color photography, annotated topographical maps, pictorial timelines, sketches of the animal and plant species first recorded during the "voyage of discovery," archival images of native cultural arts and crafts, quotes and pictures of the land Lewis and Clark viewed on their journey to the Pacific.

There are pictures of Clark's field journal and a fold-out map of the journey to put it all in perspective.

The chapters include:

Members of the Expedition - pictures of the letter from Jefferson and gorgeous

pictures of the scenery.
Underway - Bound for the Pacific through the interior of the continent
Onto the Plains - Stories of the Tribes living on the plains.
Off the Map - Confrontations with grizzly bears
Over "Those Tremendous Mountains"
On to the Sea - Rapids and finally, some pictures I recognize as home! I can almost smell
the salty sea now as I look at the pictures. We visited Fort Clatsop once with my aunt.
Homeward Bound - Humorous story about fending off the herd of bison. Yikes!
Log - Expedition Roster, Index, Credits, Animal Listings, Plant Listings, Glossary

A retelling of the greatest wilderness trip ever recorded. Thomas Schmidt and Jeremy Schmidt truly have created a magnificent keepsake of this journey into the uncharted West.

An Epic Journey!

This is a wonderfully illustrated retelling of the incredible expedition to the West and the Pacific Ocean undertaken by the Corps of Discovery, that amazing group of men (and women) who trekked over four thousand miles from St. Louis to the west coast and back over the course of two years from 1804-1806. The story of Lewis and Clark's journey to the West has been told many times, but never in such an accessible and enjoyable format as this. It is pepppered with excerpts from the expedition's meticulously kept journals and vivid descriptions of the unknown land and the native tribes they encountered in their travels into the vast Louisiana Territory. This book is bursting with beautiful photos, paintings, and drawings that draw the reader into this truly amazing story of adventure and discovery that shaped a young new nation.