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The introduction covers some main ideas of tissue engineering ' what do we want ' what are we able to do ' what do we still have to get knowledge of. After a short review of the history, the essentials of cell biology (Growth, Differentiation) are being introduced. The reader should have an idea of developmental biology to be able to follow topics like induction and morphogenesis. The authors emphasize the importance of the extracellular matrix as one of organ-prosthesis' main building blocks (ECM = scaffold; cells = function; cell signalling = integration and physiology).
The second part describes technical aspects of in-vitro organ synthesis: tissue culture and ECM, tissue culture und growth factors, bioreactors and vascularization. The third part continues with in-vivo techniques of organ reparation, exemplified by methods for substitution of the ECM of skin, peripheral nerves and meniscus.
Parts 4 ' 6 develop models for the substitution of the ECM (Collagen, BioPolymers), their implantation in the receiving organism and the resulting immunologic problems (emphasized).
Parts 7 ' 20 are concerned with the organs themselves. After few words about stem cells and gene therapy the book explains reconstruction and substitution methods for breast, heart and blood vessels, Cornea, endocrine glands, liver (very good), kidney and haematopoietic system. Biomechanical problems are outlined in the part about the musculoskeletal system. On this place tissue engineering celebrates its oldest success (cartilage substitution). Today innervation processes are being focused.
The book continues with substitutes for the senses (ear and eye), nerve cells, nerve regeneration and neural stem cells. Dents and skin could be all to make an ill patient 'healthy' by substitutes, one might think. But no, western medicine also knows something about substitutes for womb and placenta'
On me the book made a good impression. The only point is: it's quite too much text and too few pictures. It addresses medicals after their exams, practicing physicians and biologists. Chapters focus on the basic principles. There is a large number of links to more detailed publications.
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This book, in its deft construction which alternates interviews and analysis, pays hommage to the director and its sources of inspirations.
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Maybe someone out there is capable of sustaining that argument; Lanza can't. For starters, his grip on other forms of music that many of us do take seriously (such as classical, jazz and rock) is shakey at best. What do you make of an author who describes the jazz trumpeter Bobby Hackett's stints with Muzak as a departure from "improvisation dementia"? In addition to being a broad and inaccurate swipe at jazz, the comment demonstrates complete ignorance of Hackett, a musician famed for his golden tone and smooth, melodic interpretations of Dixieland and popular songs.
Or consider the following regarding easy-listening interpretations of famous rock songs: "Many from Bob Dylan, the Doors, the Beatles, the Rolling Stones, the Mamas and the Papas, R.E.M., the B-52s, U2, and Van Morrison have been refurbished from loud, plodding, adolescent thunder to something tasteful, airy, and mystical." Dylan, adolescent? Van Morrison, plodding? The Mamas and the Papas, loud? But the root problem -- and authorial prejudice -- is in his assignment of the adjectives "tasteful, airy, and mystical" to music that's best described as bland, flat, and deliberately unengaging.
"Mystical," is a term Lanza frequently applies to elevator music. Bottom line: he cannot distinguish the amniotic state of neutered consciousness that Muzak acheives from the genuine achievement of goodness, truth and beauty that can be enjoyed in better music, whether it be folk, rock, jazz or classical.
In the end, Lanza's posture shifts from being one that provokes curiousity to one that seems downright perverse. Lanza concludes his book with a sympathetic reading of the "emotional engineers" in Huxley's "Brave New World." As I read Lanza's praise of the artificial ("most of us, in our hearts, want a world tailored by Walt Disney's 'imagineers'") I couldn't help but think of George Orwell and the sad conclusion to "1984" in which the hero, numbed by falsehood, confesses his love for Big Brother.
Part of the problem, in my opinion, is that there really is no definable genre that could be called "moodsong." All music creates a mood of some sort, when it comes right down to it (whether by accident or design, what's the real difference?). And Lanza does a poor job of covering the history of the Muzak Corp. or any specific area of "easy listening" (all are drastically short-shrifted in a mere 233 pages). In defining the genre, it seems Lanza defined it too broadly -- it would take a thousand pages at least to really do justice to the material he covers -- not to mention, a lot more in-depth research than he apparently did or was willing to do.
What's more, his speculative arguments fail to convince me... I do enjoy most of the music (aesthetically) and am not ashamed to say so, but it's my right-brain, emotional side that likes it. Lanza's attempts to analyze or 'justify' easy-listening and mood music in general fall flat, and his utopian speculation just ends up sounding silly and contrived. I agree with most of the points the previous reviewer made.
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